A Methodology for Radiolabeling of the Endocannabinoid 2-Arachidonoylglycerol (2-AG)
نویسندگان
چکیده
منابع مشابه
The endocannabinoid 2-arachidonoylglycerol promotes sperm developement through activation of cannabinoid-2 receptors
The exact role of the endocannabinoid system (ECS) during spermatogenesis has not been clarified. Scientists at the University of Rome "Tor Vergata" (Italy) and at the Endocannabinoid Research Group – Consiglio Nazionale delle Ricerche (Pozzuoli, Italy) have used purified germ cell fractions representative of all phases of spermatogenesis and primary cultures of spermatogonia, to demonstrate th...
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BACKGROUND AND PURPOSE Endocannabinoids have both anti-inflammatory and neuroprotective properties against harmful stimuli. We previously demonstrated that the endocannabinoid 2-arachidonoylglycerol (2-AG) protects hippocampal neurons by limiting the inflammatory response via a CB(1) receptor-dependent MAPK/NF-κB signalling pathway. The purpose of the present study was to determine whether PPAR...
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BACKGROUND Diets rich in dairy and/or calcium (Ca) have been associated with reductions in adiposity and inflammation, but the mechanisms underlying this remain to be fully elucidated. Oxylipins and endocannabinoids are bioactive lipids, which influence energy homeostasis, adipose function, insulin signaling, and inflammation. Our objective was to determine if these metabolites associate with m...
متن کاملA novel activity of microsomal epoxide hydrolase: metabolism of the endocannabinoid 2-arachidonoylglycerol.
Microsomal epoxide hydrolase (EPHX1, EC 3.3.2.9) is a highly abundant α/β-hydrolase enzyme that is known for its catalytical epoxide hydrolase activity. A wide range of EPHX1 functions have been demonstrated including xenobiotic metabolism; however, characterization of its endogenous substrates is limited. In this study, we present evidence that EPHX1 metabolizes the abundant endocannabinoid 2-...
متن کاملA comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol.
Endogenous ligands for cannabinoid receptors ("endocannabinoids") include the lipid transmitters anandamide and 2-arachidonoylglycerol (2-AG). Endocannabinoids modulate a diverse set of physiological processes and are tightly regulated by enzymatic biosynthesis and degradation. Termination of anandamide signaling by fatty acid amide hydrolase (FAAH) is well characterized, but less is known abou...
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ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 2011
ISSN: 0022-3263,1520-6904
DOI: 10.1021/jo102277q