A Macroglobulin with Inhibitory Activity Against Coagulation Factor VIII

A macroglobulin with inhibitory activity against coagulation factor VIII.

H EMOSTATIC DISORDERS with a varying incidence of bleeding, are common in the dysproteinemias, and are characteristic of the macroglobulinemia of \\Taldenstr#{246}m These abnormalities are most frequently attributed to abnormal platelet function,1 and depression of specific clotting factors appears to be a rare occurrence. Nilehn2 includes four instances of antihemophilic globulin ( factor VIII...

Increased coagulation factor VIII activity in patients with familial hypercholesterolemia.

Acknowledgments: The authors thank Dr Reinhard Sedlmeier at Ingenium Pharmaceuticals GmbH for kindly providing them with the pSPL3b exon trapping vector and Dr Alex McMillan at Stanford University for statistical consultation. They also express gratitude to Parveen Abidi and Larry Okumoto of the Stanford Hematology Division/Cancer Institute Tissue Bank. G.P.N. was supported by National Institut...

Lectin activity of the coagulation factor VIII/von Willebrand complex.

The human coagulation factor VIII (FVIII) is essential in the intrinsic pathway of blood coagulation and circulates mainly as a non-covalently bound complex with the von Willebrand factor (VWF). This complex (FVIII/VWF) protects FVIII from degradation and cellular uptake, although no biological role has been identified yet for this complex. The FVIII/VWF complex was purified from a healthy dono...

Coagulation Therapy in Hemophilia A and its Relation to Factor VIII Inhibitor in Northeast of Iran

FACTOR V AND VIII INHIBITOR IN PATIENTS WITH COMBINED FACTOR V AND VIII DEFICIENCY

Patients with coagulation factor(s) deficiency who use coagulation therapy are susceptible to forming inhibitors against coagulation factor(s). In this survey we detected factor V and VIII inhibitor in ten patients with combined deficiency of factors V and VIII from north east of Iran (Khorassan province). It was revealed in our survey that eight patients had both factor V and factor VIII i...