A low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers
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چکیده
منابع مشابه
Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide in Healthy Subjects
BACKGROUND AND OBJECTIVE Lysergic acid diethylamide (LSD) is used recreationally and in clinical research. The aim of the present study was to characterize the pharmacokinetics and exposure-response relationship of oral LSD. METHODS We analyzed pharmacokinetic data from two published placebo-controlled, double-blind, cross-over studies using oral administration of LSD 100 and 200 µg in 24 and...
متن کاملImmunoassay analysis of lysergic acid diethylamide.
Screening large numbers of urine samples for drugs of abuse is typically accomplished using immunoassays that allow for processing large numbers of samples without the requirement of sample preparation before analysis. Until fairly recently, screening of lysergic acid diethylamide (LSD) in urine samples could only be accomplished by the use of radioimmunoassays (RIA). Recently, new nonisotopic ...
متن کاملInterference with testing for lysergic acid diethylamide.
We found a high rate (4.2%) of positive results for lysergic acid diethylamide (LSD) by Emit in 1898 urine samples that were submitted primarily from psychiatric patients for drugs-of-abuse (DOA) testing. Specimens that tested positive for LSD by Emit subsequently tested negative for LSD with two RIAs. Furthermore, LSD was not detected in randomly selected Emit-positive urine samples by gas chr...
متن کاملThe metabolism of lysergic acid diethylamide.
The unavailability of a suitable preanaesthetic medicament is discussed. A double blind comparison of placebo, meprobamate and pentobarbital as preanaesthetic medicants for regional procedures is presented. The authors have determined the effects of each of these treatments on patient's apprehension, cooperation, drowsiness, reaction to painful stimuli, talkativeness, nausea and emesis. The ana...
متن کاملLysergic Acid Diethylamide and Psilocybin Revisited.
The past decade brought the beginnings of a renaissance in research on psychedelic drugs. Two articles in this issue of Biological Psychiatry signify that the resurrection of this longignored topic has begun to mature and bear at least the promise of fruit. In the early 1970s, the onset of the “War on Drugs” brought with it a near-total hiatus in serious research on psychedelic drugs, especiall...
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ژورنال
عنوان ژورنال: Journal of Psychopharmacology
سال: 2020
ISSN: 0269-8811,1461-7285
DOI: 10.1177/0269881120940937