A long sought after “receptor” for ERFE?

Mincle is a long sought receptor for mycobacterial cord factor

Mycobacterium tuberculosis is a leading killer worldwide, yet the adjuvancy of its cell wall has proven to be a valuable therapeutic tool for vaccination and immunotherapy. Much research effort has focused on the mycobacterial glycolipid trehalose-6,6'-dimycolate (TDM), a potent immunostimulant that is also known as cord factor. Now, the identification of the monocyte-inducible C-type lectin (M...

β1 integrin is a long-sought sensor for tauroursodeoxycholic acid.

DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer.

For decades, radiotherapy and chemotherapy were the two only approaches exploiting DNA repair processes to fight against cancer. Nowadays, cancer therapeutics can be a major challenge when it comes to seeking personalized targeted medicine that is both effective and selective to the malignancy. Over the last decade, the discovery of new targeted therapies against DNA damage signalling and repai...

Synthesis of long-sought C66 with exohedral stabilization.

Previously reported fused-pentagon fullerenes stabilized by exohedral derivatization do not share the same cage with those stabilized by endohedral encapsulation. Herein we report the crystallographic identification of (#4348)C66Cl10, which has the same cage as that of previously reported Sc2@C66. According to the geometrical data of (#4348)C66Cl10, both strain relief (at the fused pentagons) a...

Cause sought for student illness

Food p o iso n in g is be ing c o n ­ s idered by the D epa rtm e n t o f En­ v iro n m e n ta l H ealth and Safety (D E H S ) as a possib le cause o f the recen t surge o f ga s tro e n te ritis am ong N o rth Q uad students. No firm ev idence has been fo u nd yet to co n n ec t the N o tre Dam e Food Service w ith the illness. “ I t doesn 't seem lik e ly i t co u ld be food p o is o n in g ,...