A limited contribution of Ca2+current facilitation to paired-pulse facilitation of transmitter release at the rat calyx of Held

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A limited contribution of Ca2+ current facilitation to paired-pulse facilitation of transmitter release at the rat calyx of Held.

Recent studies have suggested that transmitter release facilitation at synapses is largely mediated by presynaptic Ca(2+) current facilitation, but the exact contribution of Ca(2+) current facilitation has not been determined quantitatively. Here, we determine the contribution of Ca(2+) current facilitation, and of an increase in the residual free Ca(2+) concentration ([Ca(2+)](i)) in the nerve...

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ژورنال

عنوان ژورنال: The Journal of Physiology

سال: 2008

ISSN: 0022-3751

DOI: 10.1113/jphysiol.2008.155838