A latrophilin/CL-1-like GPS domain in polycystin-1

A latrophilin/CL-1-like GPS domain in polycystin-1

The roles of different structures Limbic and frontal structures are best thought of as mediating declarative memory but what role do these different structures play in the process of memory? The hippocampus is divided into four ‘fields’ and one of these, CA1, receives inputs from all parts of the prefrontal cortex. Moreover, neurons in CA1 have a very high degree of interconnectivity. Memory fo...

Polycystin - 1 and Polycystin - 2 Complexes

In silico prediction of B cell epitopes of the extracellular domain of insulin-like growth factor-1 receptor

The insulin-like growth factor-1 receptor (IGF-1R) is a transmembrane receptor with tyrosine kinase activity. The receptor plays a critical role in cancer. Using monoclonal antibodies (MAbs) against the IGF-1R, typically blocks ligand binding and enhances down-regulation of the cell-surface IGF-1R. Some MAbs such as cixutumumab are under clinical trial investigation. Targeting multiple distinct...

Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner.

Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited nephropathy responsible for 4%-10% of end-stage renal disease cases. Mutations in the genes encoding polycystin-1 (PC1, PKD1) or polycystin-2 (PC2, PKD2) cause ADPKD, and PKD1 mutations are associated with more severe renal disease. PC1 has been shown to form a complex with PC2, and the severity of PKD1-mediated disease ...

The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease.

Most cases of autosomal dominant polycystic kidney disease (ADPKD) are the result of mutations in the PKD1 gene. The PKD1 gene codes for a large cell-surface glycoprotein, polycystin-1, of unknown function, which, based on its predicted domain structure, may be involved in protein-protein and protein-carbohydrate interactions. Approximately 30% of polycystin-1 consists of 16 copies of a novel p...