A lab-on-a-chip for detection of nerve agent sarin in blood

A lab-on-a-chip for detection of nerve agent sarin in blood.

Sarin (C(4)H(10)FO(2)P,O-isopropyl methylphosphonofluoridate) is a colourless, odourless and highly toxic phosphonate that acts as a cholinesterase inhibitor and disrupts neuromuscular transmission. Sarin and related phosphonates are chemical warfare agents, and there is a possibility of their application in a military or terrorist attack. This paper reports a lab-on-a-chip device for detecting...

A compact lab-on-a-chip nanosensor for glycerol detection

Electrochemical 'Lab on a chip' for Toxicity Detection in Water

An electrochemical 'Lab-on-a-chip' for water toxicity detection is presented. This miniaturized device containing an array of nano liter electrochemical cells, which integrates bacteria and can emulate physiological reactions in response to different chemicals. Bacteria, which have been genetically engineered to respond to environmental stress, act as a sensor element and trigger a sequence of ...

Droplet-based microfluidic lab-on-a-chip for glucose detection

A microfluidic lab-on-a-chip (LoC) platform for in vitro measurement of glucose for clinical diagnostic applications is presented in this paper. The LoC uses a discrete droplet format in contrast to conventional continuous flow microfluidic systems. The droplets act as solution-phase reaction chambers and are manipulated using the electrowetting effect. Glucose is measured using a colorimetric ...

A High-sensitivity On-chip Fluorescence Detection for Lab-on-a-chip

In this paper, we present an improved high-sensitivity approach for on-chip fluorescence-based measurements for disposable lab-on-a-chip (LOC). We use a bilayer organic photodiode (OPD), cross-polarization, and improved integration to enhance Rhodamine 6G limit of detection (LOD) to 10 nM, which is a 10-100 fold improvement over current reports in literature. A prototype system was fully charac...