A hybrid clustering of protein binding sites
نویسندگان
چکیده
منابع مشابه
A hybrid clustering of protein binding sites.
The Protein Data Bank contains the description of approximately 27 000 protein-ligand binding sites. Most of the ligands at these sites are biologically active small molecules, affecting the biological function of the protein. The classification of their binding sites may lead to relevant results in drug discovery and design. Clusters of similar binding sites were created here by a hybrid, sequ...
متن کاملStudy of PKA binding sites in cAMP-signaling pathway using structural protein-protein interaction networks
Backgroud: Protein-protein interaction, plays a key role in signal transduction in signaling pathways. Different approaches are used for prediction of these interactions including experimental and computational approaches. In conventional node-edge protein-protein interaction networks, we can only see which proteins interact but ‘structural networks’ show us how these proteins inter...
متن کاملOPTIMIZATION OF FUZZY CLUSTERING CRITERIA BY A HYBRID PSO AND FUZZY C-MEANS CLUSTERING ALGORITHM
This paper presents an efficient hybrid method, namely fuzzy particleswarm optimization (FPSO) and fuzzy c-means (FCM) algorithms, to solve the fuzzyclustering problem, especially for large sizes. When the problem becomes large, theFCM algorithm may result in uneven distribution of data, making it difficult to findan optimal solution in reasonable amount of time. The PSO algorithm does find ago...
متن کاملSpatial clustering of protein binding sites for template based protein docking
MOTIVATION In recent years, much structural information on protein domains and their pair-wise interactions has been made available in public databases. However, it is not yet clear how best to use this information to discover general rules or interaction patterns about structural protein-protein interactions. Improving our ability to detect and exploit structural interaction patterns will help...
متن کاملStructural Descriptors of Protein-Protein Binding Sites
Structural bioinformatics provides new tools for investigating protein-protein interactions at the molecular level. We present two types of structural descriptors for efficiently representing and comparing protein-protein binding sites and surface patches. The descriptors are based on distributions of distances between five types of functional atoms, thereby capturing the spatial arrangement of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEBS Journal
سال: 2010
ISSN: 1742-464X
DOI: 10.1111/j.1742-4658.2010.07578.x