A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance
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چکیده
منابع مشابه
Mucociliary clearance, airway inflammation and nasal symptoms in urban motorcyclists
OBJECTIVES There is evidence that outdoor workers exposed to high levels of air pollution exhibit airway inflammation and increased airway symptoms. We hypothesized that these workers would experience increased airway symptoms and decreased nasal mucociliary clearance associated with their exposure to air pollution. METHODS In total, 25 non-smoking commercial motorcyclists, aged 18-44 years, ...
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To the Editor: We read with interest the report by García Pachón et al1 regarding idiopathic chronic lithoptysis and the letter by Roig Vázquez et al2 on lithoptysis in a patient with primary ciliary dyskinesia (PCD). Complementing these observations, we recently completed an analysis of lithoptysis and airway calcification in a large cohort (n=142) of wellcharacterized PCD patients.3 We identi...
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Mucociliary airway clearance is an innate defense mechanism that protects the lung from harmful effects of inhaled pathogens. In order to escape mechanical clearance, airway pathogens including Streptococcus pneumoniae (pneumococcus) are thought to inactivate mucociliary clearance by mechanisms such as slowing of ciliary beating and lytic damage of epithelial cells. Pore-forming toxins like pne...
متن کاملA mechanism of airway injury in an epithelial model of mucociliary clearance
We studied the action of sodium metabisulphite on mucociliary transport in a frog palate epithelial injury model, hypothesizing that it may be useful for the study of mechanisms of airway injury. Sodium metabisulphite (MB) releases SO2 on contact with water. SO2 is a pollutant in automobile fumes and may play a role in the exacerbation of airway disease symptoms. We first investigated its effec...
متن کاملCyclosporin A reduces airway mucus secretion and mucociliary clearance in rats.
PURPOSE To assay the effects of cyclosporin A on mucus secretion from goblet cells and on mucociliary transport in situ in rats. METHODS Twenty-one male Wistar rats were assigned to 3 groups: control (n = 5), saline (n = 8), and cyclosporin A (n = 8). After 30 days of drug therapy, the rats were killed, and the lungs were removed from the thoracic cavity. Mucus samples were collected, and the...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2020
ISSN: 1078-8956,1546-170X
DOI: 10.1038/s41591-019-0730-x