A high-dose rapamycin treatment alleviates hepatopulmonary syndrome in cirrhotic rats
نویسندگان
چکیده
منابع مشابه
Frequency of hepatopulmonary syndrome in cirrhotic patients.
OBJECTIVE To determine the frequency of Hepatopulmonary Syndrome (HPS) in patients with cirrhosis of the liver. STUDY DESIGN Observational cross-sectional study. PLACE AND DURATION OF STUDY Department of Gastroenterology and Hepatology, Shaikh Zayed Hospital, Lahore, from April 2005 to March 2006. PATIENTS AND METHODS Fifty consecutive patients admitted with liver cirrhosis were recruited...
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Liver fibrosis causes portal hypertension which dilates collateral vasculature and enhances extra-hepatic angiogenesis including intrapulmonary shunts, which subsequently complicates with hepatopulmonary syndrome (HPS). Metformin is an anti-diabetic agent which has anti-inflammation and antiangiogenesis properties. HPS is a severe complication of liver cirrhosis which is characterized by deoxyg...
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HPS (hepatopulmonary syndrome) is characterized by oxygen desaturation in patients with chronic liver disease. The initiation of HPS comes from abnormal pulmonary vasodilatation and/or angiogenesis. In the present study, we evaluated anti-angiogenesis therapy using sorafenib in experimental HPS animals. HPS was induced by CBDL (common bile duct ligation) in rats. A 2-week 10 mg·(kg of body weig...
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Inhibition of tumour necrosis factor-alpha (TNF-alpha), levels of which are increased in the blood of cirrhotic rats, prevents hyperdynamic circulatory state, mainly by decreasing the vascular overproduction of nitric oxide. Hepatopulmonary syndrome, which is characterised by intrapulmonary vascular dilatation and increased alveolar to arterial oxygen tension difference (PA-a,O2), is mainly rel...
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ژورنال
عنوان ژورنال: Journal of the Chinese Medical Association
سال: 2020
ISSN: 1726-4901
DOI: 10.1097/jcma.0000000000000194