A Heterochromatin Domain Forms Gradually at a New Telomere and Is Dynamic at Stable Telomeres
نویسندگان
چکیده
منابع مشابه
Telomere Binding Protein Taz1 Establishes Swi6 Heterochromatin Independently of RNAi at Telomeres
BACKGROUND The telomere is a specialized heterochromatin conserved among eukaryotes. However, it remains unknown how heterochromatin protein 1 (HP1) is recruited to telomeres and how telomere heterochromatin is formed. In fission yeast, the RNAi (RNA interference)-RITS (RNA-induced initiation of transcriptional silencing) pathway initiates heterochromatin formation at the centromeres and the si...
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Heterochromatin regulation of gene expression exhibits epigenetic inheritance, in which some feature of the structure is retained and can reseed formation in new cells. To understand the cell-cycle events that influence heterochromatin assembly and maintenance in budding yeast, we have conducted two types of experiments. First we have examined the kinetics of heterochromatin spreading at telome...
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rimethylation of histone H3 lysine 9 and the subsequent binding of heterochromatin protein 1 (HP1) mediate the formation and maintenance of pericentromeric heterochromatin. Trimethylation of H3K9 is governed by the histone methyltransferase SUV39H1. Recent studies of HP1 dynamics revealed that HP1 is not a stable component of heterochromatin but is highly mobile (Cheutin, T., A.J. McNairn, T. J...
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The linearity of chromosomes creates two major problems for eukaryotic cells: the end-replication problem and the endprotection problem. The end-replication problem stems from the inherent inability of the replication machinery to fully duplicate linear templates. The endprotection problem refers to the propensity of linear chromosome ends to be recognized as DNA double-strand breaks (DSBs). Bo...
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During meiosis, telomeres cluster and promote homologous chromosome pairing. Telomere clustering requires the interaction of telomeres with the nuclear membrane proteins SUN (Sad1/UNC-84) and KASH (Klarsicht/ANC-1/Syne homology). The mechanism by which telomeres gather remains elusive. In this paper, we show that telomere clustering in fission yeast depends on microtubules and the microtubule m...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2018
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.00393-17