منابع مشابه
A genomic perspective on protein families.
In order to extract the maximum amount of information from the rapidly accumulating genome sequences, all conserved genes need to be classified according to their homologous relationships. Comparison of proteins encoded in seven complete genomes from five major phylogenetic lineages and elucidation of consistent patterns of sequence similarities allowed the delineation of 720 clusters of orthol...
متن کاملGenomic classification of protein-coding gene families.
This chapter reviews analytical tools currently in use for protein classification, and gives an overview of the C. elegans proteome. Computational analysis of proteins relies heavily on hidden Markov models of protein families. Proteins can also be classified by predicted secondary or tertiary structures, hydrophobic profiles, compositional biases, or size ranges. Strictly orthologous protein f...
متن کاملCore deformations in protein families: a physical perspective.
An analysis is presented on how structural cores change shape within protein families, and whether or not there is a relationship between these structural changes and the vibrational modes that proteins experiment due to topological constraints. A set of 13 representative and well-populated protein families are studied. The evolutionary directions of deformation are obtained by applying a new m...
متن کاملA genomic perspective on vitamin D signaling.
The vitamin D receptor (VDR) is a ligand-inducible transcription factor whose target genes play key roles in cellular metabolism, bone formation, cellular growth, differentiation and in controlling inflammation. Many of these VDR target genes are also involved in dysregulated pathways leading to common human diseases, such as cancer. The activation of VDR by natural and synthetic ligands may im...
متن کاملA genomic perspective of protein kinases in Plasmodium falciparum.
Protein kinases are central to regulation of cellular signaling in the eukaryotes. Well-conserved and lineage-specific protein kinases have previously been identified from various completely sequenced genomes of eukaryotes. The current work describes a genome-wide analysis for protein kinases encoded in the Plasmodium falciparum genome. Using a few different profile matching methods, we have id...
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ژورنال
عنوان ژورنال: Science
سال: 1997
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.278.5338.631