A Gene Network Perspective on Axonal Regeneration
نویسندگان
چکیده
منابع مشابه
A Gene Network Perspective on Axonal Regeneration
The regenerative capacity of injured neurons in the central nervous system is limited due to the absence of a robust neuron-intrinsic injury-induced gene response that supports axon regeneration. In peripheral neurons axotomy induces a large cohort of regeneration-associated genes (RAGs). The forced expression of some of these RAGs in injured neurons has some beneficial effect on axon regenerat...
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Because axonal damage and loss are frequent phenomena of multiple sclerosis and other types of neurodegenerative diseases, and because the effects can be devastating clinically, attention has been focused on repair to axons. However, axon regeneration appears to be inhibited via a variety of possible cellular pathways and molecules. In the following article, several of these pathways are examin...
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Chondroitin sulphate proteoglycans (CSPGs) upregulated in the glial scar inhibit axon regeneration via their sulphated glycosaminoglycans (GAGs). Chondroitin 6-sulphotransferase-1 (C6ST-1) is upregulated after injury leading to an increase in 6-sulphated GAG. In this study, we ask if this increase in 6-sulphated GAG is responsible for the increased inhibition within the glial scar, or whether i...
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How neurons connect in the complex circuits of neocortex is one of the fundamental problems in neuroscience. Anatomical techniques are used to trace the connection pathways involving axonal and dendritic trees, and electrophysiological recordings are applied to probe the connections between two or several neurons in the circuit. More recently, optical methods such as uncaging of glutamate and c...
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ژورنال
عنوان ژورنال: Frontiers in Molecular Neuroscience
سال: 2011
ISSN: 1662-5099
DOI: 10.3389/fnmol.2011.00046