A dual osteoconductive-osteoprotective implantable device for vertical alveolar ridge augmentation

Repair of large oral bone defects such as vertical alveolar ridge augmentation could benefit from the rapidly developing additive manufacturing technology used to create personalized osteoconductive devices made porous tricalcium phosphate/hydroxyapatite (TCP/HA)-based bioceramics. These can be also hydrogel carriers improve their osteogenic potential. However, TCP/HA constructs are prone brittle fracture, therefore use in clinical situations is difficult. As a solution, we propose protection this multi-material (herein called “core”) with shape-matched “cover” biocompatible poly-ɛ-caprolactone (PCL), which ductile, and thus more resistant polymeric material. In report, present workflow starting patient-specific medical scan Digital Imaging Communications Medicine (DICOM) format files, up design 3D printing hydrogel-loaded core its corresponding PCL cover. This cover facilitate anchoring device patient's defect site via fixing screws. The large, linearly aligned pores bioceramic core, sizes, filling an alginate were analyzed by micro-CT. Moreover, created finite element analysis (FEA) model dual-function device, permits simulation mechanical behavior various anticipated situations, well optimization before surgery. conclusion, designed 3D-printed novel, structurally complex osteoconductive-osteoprotective properties suitable for large-defect regeneration.