A Dissolution Test for Finasteride in Immediate-Release Capsules
نویسندگان
چکیده
منابع مشابه
A Dissolution Test for Finasteride in Immediate-Release Capsules
In vitro dissolution tests for solid oral dosage forms are extremely important to ensure the quality of these products. However, no dissolution test has been reported for finasteride (FNS) in immediate-release capsules. The aims of this work were to optimize a dissolution method for FNS capsules, validate the analytical method, and evaluate three different commercial products. The best in vitro...
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Rabeprazole sodium (RAB) dissolved in acidic media is accompanied by its degradation in the course of dissolution testing. To develop and establish the accumulative release profiles of ACIPHEX(®) Sprinkle (RAB) delayed-release capsules (ACIPHEX(®) Sprinkle) in acidic media using USP apparatus 2 (paddle apparatus) as a dissolution tester, the issues of determination of accumulative release amoun...
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Development of an appropriate dissolution method for quality control purposes requires consideration of many factors and a balance of different needs. The method is typically distinctive to each drug product because of the unique characteristics of the active ingredient, the formulation, and the manufacturing process. The method development and selection process remains subjective due to the po...
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Drug dissolution studies are commonly conducted using compendial methods employing USP Paddle and Basket apparatuses. In many cases, dissolution studies can be of limited benefit especially for product-dependent dissolution procedures like in extended release (ER) formulations. The high variability in dissolution testing, that is not productrelated, emphasizes the need for developing new method...
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Introduction: In vitro drug release and dissolution testing play an important role in pharmaceutical formulation development and quality control. Poorly soluble candidate molecules constitute a major challenge for the formulation development since the insufficient solubility causes problems for in vitro and in vivo assays, with consequent increased risk of attrition and costs (Di et al., 2012),...
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ژورنال
عنوان ژورنال: Dissolution Technologies
سال: 2013
ISSN: 1521-298X
DOI: 10.14227/dt200313p25