A dissection model for mapping complex traits
نویسندگان
چکیده
منابع مشابه
A non-stationary model for functional mapping of complex traits
SUMMARY Understanding the genetic control of growth is fundamental to agricultural, evolutionary and biomedical genetic research. In this article, we present a statistical model for mapping quantitative trait loci (QTL) that are responsible for genetic differences in growth trajectories during ontogenetic development. This model is derived within the maximum likelihood context, implemented with...
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Systems genetics relies on common genetic variants to elucidate biologic networks contributing to complex disease-related phenotypes. Mice are ideal model organisms for such approaches, but linkage analysis has been only modestly successful due to low mapping resolution. Association analysis in mice has the potential of much better resolution, but it is confounded by population structure and in...
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Many statistical tools have been developed to map and study the genetic architecture of complex phenotypes important to agriculture, biology, and biomedicine [1-9]. Thanks to recent advances in sequencing and genotyping technologies, DNA-based marker data crucial for genetic mapping can be generated almost with no limit. A new challenge that faces methodological development is how to dissect a ...
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ژورنال
عنوان ژورنال: The Plant Journal
سال: 2019
ISSN: 0960-7412,1365-313X
DOI: 10.1111/tpj.14185