A detailed genetic map of the chromosome 7 bronchial hyper-responsiveness locus
نویسندگان
چکیده
منابع مشابه
Bronchial hyper-responsiveness after human cardiopulmonary transplantation.
1. Bronchial responsiveness to inhaled methacholine was studied in ten heart-lung transplant (HLT) recipients a mean 10.6 months (range 1.5-28 months) post-HLT and in ten normal subjects. 2. The mean provocation dose of methacholine producing a 20% fall in FEV1 (PD20 FEV1) was significantly lower in the HLT recipients (1.70 +/- 3.96 mg vs 11.55 +/- 3.79 mg; P less than 0.001), as was the mean p...
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We herein report a detailed physical map of the horse Y chromosome. The euchromatic region of the chromosome comprises approximately 15 megabases (Mb) of the total 45- to 50-Mb size and lies in the distal one-third of the long arm, where the pseudoautosomal region (PAR) is located terminally. The rest of the chromosome is predominantly heterochromatic. Because of the unusual organization of the...
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The inter-relationship between the perception of bronchoconstriction, bronchial hyper-responsiveness and temporal adaptation in asthma is still a matter of debate. In a total of 52 stable asthmatic patients, 32 without airway obstruction ¿forced expiratory volume in 1 s (FEV(1))/vital capacity (VC) 84.1% (S.D. 7.9%), and 20 with airway obstruction [FEV(1)/VC 60% (4%)], we assessed the perceptio...
متن کاملFactors contributing to bronchial hyper-responsiveness in asthma.
Asthma is a condition characterized by recurrent breathlessness, cough or wheeze caused by variable or intermittent narrowing of intrapulmonary airways [ 13. All asthmatic individuals have hyper-responsive intrathoracic airways and because of this most experience acute attacks of bronchoconstriction at times. A great deal of work has been done to understand this hyperresponsive state of the air...
متن کاملTesting bronchial hyper-responsiveness: provocation or peak expiratory flow variability?
BACKGROUND Assessing bronchial hyper-responsiveness (BHR) is a main diagnostic criterion of asthma. Provocation testing is not readily available in general practice, but peak expiratory flow (PEF) is. Several guidelines promote the use of PEF variability as a diagnostic tool for BHR. This study tested the agreement between histamine challenge testing and PEF variability, and the consequences fo...
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ژورنال
عنوان ژورنال: European Journal of Human Genetics
سال: 2002
ISSN: 1018-4813,1476-5438
DOI: 10.1038/sj.ejhg.5200787