A Defective, Rearranged Epstein-Barr Virus Genome in EBER-Negative and EBER-Positive Hodgkin's Disease
نویسندگان
چکیده
منابع مشابه
Replacement of the Epstein-Barr virus plasmid with the EBER plasmid in Burkitt's lymphoma cells.
Transfection of an Epstein-Barr virus (EBV)-encoded plasmid containing EBER caused a substantial decrease in the level of plasmid containing EBV in Akata and Mutu Burkitt's lymphoma (BL) lines, but failed to do so in other BL lines. The results suggest that EBER could replace the role of EBV, but other EBV products also play a role in the growth of BL.
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The Epstein-Barr virus (EBV)-encoded RNAs, EBER-1 and EBER-2, are highly abundant noncoding nuclear RNAs expressed during all forms of EBV latency. The EBERs have been shown to impart significant tumorigenic potential upon EBV-negative Burkitt lymphoma (BL) cells and to contribute to the growth potential of other B-cell lymphoma-, gastric carcinoma-, and nasopharyngeal carcinoma-derived cell li...
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The oncogenic Epstein-Barr virus (EBV) expresses 44 mature microRNAs and two non-coding EBER RNAs of 167 (EBER1) and 172 (EBER2) nt length. MiRNA profiling of NK/T cell lines and primary cells and Northern blotting of EBV-infected cell lines and primary tumors revealed processing of EBER1 to short 5′-derived RNAs of approximately 23, 52 and 70 nt (EBER123, EBER152, and EBER170) and of EBER2 to ...
متن کاملAbbreviations: BM: bone marrow, CAEBV: chronic active Epstein-Barr virus infection, EBV: Epstein-Barr virus, EBER: Epstein-Barr virus-encoded mRNA, EBNA: Epstein-Barr virus-nuclear antigen, HLH: hemophagocytic lymphohistiocytosis, HIV: human immunodeficiency virus, HMB: hypersensitivity to mosquito
Affiliations: 1. Department of Pediatrics, 2. Department of Medicine and Biosystemic Science, 3. Department of Medicine, and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 4. Department of Infectious Diseases, National Research Institute for Child Health and Development, Tokyo, 5. Department of 2 Pathology, Faculty of Medicine, Kurume University School o...
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Background and Aims: Epstein-Barr virus (EBV) infection is very common in the population. Virus belongs to the family Herpesviridae, whose representatives are characterized by the ability to cause the human body latent persistent infections. The goal of this study was to assess EBV infection frequency using PCR method in samples from inflammatory eye disease, in comparison with EBV presence in ...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2002
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)64900-0