A Decision Rule for Quantitative Trait Locus Detection Under the Extended Bayesian LASSO Model
نویسندگان
چکیده
منابع مشابه
A decision rule for quantitative trait locus detection under the extended Bayesian LASSO model.
Bayesian shrinkage analysis is arguably the state-of-the-art technique for large-scale multiple quantitative trait locus (QTL) mapping. However, when the shrinkage model does not involve indicator variables for marker inclusion, QTL detection remains heavily dependent on significance thresholds derived from phenotype permutation under the null hypothesis of no phenotype-to-genotype association....
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The mapping of quantitative trait loci (QTL) is to identify molecular markers or genomic loci that influence the variation of complex traits. The problem is complicated by the facts that QTL data usually contain a large number of markers across the entire genome and most of them have little or no effect on the phenotype. In this article, we propose several Bayesian hierarchical models for mappi...
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The Bayesian LASSO (BL) has been pointed out to be an effective approach to sparse model representation and successfully applied to quantitative trait loci (QTL) mapping and genomic breeding value (GBV) estimation using genome-wide dense sets of markers. However, the BL relies on a single parameter known as the regularization parameter to simultaneously control the overall model sparsity and th...
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A reversible jump Markov chain Monte Carlo (MCMC) algorithm is illustrated to infer the number of quantitative trait loci (QTL) a ecting a phenotypic trait, their chromosomal locations, and their e ects. A multi-loci model is t to quantitative trait and molecular marker data, with the trait response modeled as a linear function of the additive and dominance e ects of the unknown QTL genotypes. ...
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In the case of selective genotyping, the usual permutation test to establish statistical significance for quantitative trait locus (QTL) mapping can give inappropriate significance thresholds, especially when the phenotype distribution is skewed. A stratified permutation test should be used, with phenotypes shuffled separately within the genotyped and ungenotyped individuals.
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ژورنال
عنوان ژورنال: Genetics
سال: 2012
ISSN: 1943-2631
DOI: 10.1534/genetics.111.130278