A critical survey of average distances between catalytic carboxyl groups in glycoside hydrolases
نویسندگان
چکیده
منابع مشابه
REVIEW Glycoside Hydrolases: Catalytic Base/Nucleophile Diversity
Recent studies have shown that a number of glycoside hydrolase families do not follow the classical catalytic mechanisms, as they lack a typical catalytic base/ nucleophile. A variety of mechanisms are used to replace this function, including substrate-assisted catalysis, a network of several residues, and the use of non-carboxylate residues or exogenous nucleophiles. Removal of the catalytic b...
متن کاملHydration of vinyl ether groups by unsaturated glycoside hydrolases and their role in bacterial pathogenesis.
Many pathogenic microorganisms invade mammalian and/or plant cells by producing polysaccharide-degrading enzymes (lyases and hydrolases). Mammalian glycosaminoglycans and plant pectins that form part of the cell surface matrix are typical targets for these microbial enzymes. Unsaturated glycoside hydrolase catalyzes the hydrolytic release of an unsaturated uronic acid from oligosaccharides, whi...
متن کاملGlycoside Hydrolases across Environmental Microbial Communities
Across many environments microbial glycoside hydrolases support the enzymatic processing of carbohydrates, a critical function in many ecosystems. Little is known about how the microbial composition of a community and the potential for carbohydrate processing relate to each other. Here, using 1,934 metagenomic datasets, we linked changes in community composition to variation of potential for ca...
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ژورنال
عنوان ژورنال: Proteins: Structure, Function, and Bioinformatics
سال: 2014
ISSN: 0887-3585
DOI: 10.1002/prot.24528