A convenient enantioselective decarboxylative aldol reaction to access chiral α-hydroxy esters using β-keto acids
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چکیده
منابع مشابه
A convenient enantioselective decarboxylative aldol reaction to access chiral α-hydroxy esters using β-keto acids
We show a convenient decarboxylative aldol process using a scandium catalyst and a PYBOX ligand to generate a series of highly functionalized chiral α-hydroxy esters. The protocol tolerates a broad range of β-keto acids with inactivated aromatic and aliphatic α-keto esters. The possible mechanism is rationalized.
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ژورنال
عنوان ژورنال: Beilstein Journal of Organic Chemistry
سال: 2014
ISSN: 1860-5397
DOI: 10.3762/bjoc.10.95