A concise enantioselective synthesis and cytotoxic evaluation of the anticancer rotenoid deguelin enabled by a tandem Knoevenagel/conjugate addition/decarboxylation sequence
نویسندگان
چکیده
منابع مشابه
Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid.
Deguelin, a natural product isolated from Mundulea sericea (Leguminosae), was shown previously to mediate strong inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity in cell culture and to reduce the formation of preneoplastic lesions when mouse mammary glands were exposed to 7,12-dimethylbenz(a)anthracene. As reported currently, deguelin was s...
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ژورنال
عنوان ژورنال: Chemical Science
سال: 2013
ISSN: 2041-6520,2041-6539
DOI: 10.1039/c3sc50424g