A computational modeling and molecular dynamics study of the Michaelis complex of human protein Z-dependent protease inhibitor (ZPI) and factor Xa (FXa)
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چکیده
منابع مشابه
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15 صفحه اولStructural basis for catalytic activation of protein Z-dependent protease inhibitor (ZPI) by protein Z.
The anticoagulant serpin, protein Z-dependent protease inhibitor (ZPI), is catalytically activated by its cofactor, protein Z (PZ), to regulate the function of blood coagulation factor Xa on membrane surfaces. The X-ray structure of the ZPI-PZ complex has shown that PZ binds to a unique site on ZPI centered on helix G. In the present study, we show by Ala-scanning mutagenesis of the ZPI-binding...
متن کاملPolymorphisms of the protein Z-dependent protease inhibitor (ZPI) gene and the risk of venous thromboembolism.
Thromb Haemost 2006; 95: 909–10 Dear Sir, Protein Z-dependent protease inhibitor (ZPI), together with its cofactor protein Z (PZ), inhibits activated factor Xa (Xa) (1–3). Studies in mice showed that the PZ null genotype increases the mortality in utero of homozygous factor V Leiden mice due to vascular thrombosis and hepatic fibrin deposition (4), suggesting a role for the PZ-ZPI pathway in th...
متن کاملThe protein Z/protein Z-dependent protease inhibitor complex.
Protein Z (PZ) is a vitamin K-dependent factor identified in human plasma in 1984 but it has no enzymatic activity. It is a cofactor of a serpin, the protein Z-dependent protease inhibitor (ZPI), and the complex PZ/ZPI inhibits activated factor X on phospholipid surfaces. In mice, the disruption of PZ or ZPI gene is asymptomatic, but enhances the thrombotic phenotype and mortality of other thro...
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ژورنال
عنوان ژورنال: Journal of Molecular Modeling
سال: 2009
ISSN: 1610-2940,0948-5023
DOI: 10.1007/s00894-008-0444-3