A comprehensive array of gray matter labels for the MIITRA atlas: Interoperability with complementary atlases

Background A comprehensive array of gyral-based,cytoarchitecture-based,and functional connectivity-based gray matter labels were constructed in the Multichannel Illinois Institute Technology & Rush university Aging (MIITRA) atlas space order to enhance functionality and its interoperability with complementary atlases. Method T1w images from 400 older adults included construction MIITRA (50%male;64.9-98.9 years age) processed Freesurfer’s standard recon-all pipeline. The Freesurfer outputs for all manually edited. Parcellations Yeo,Desikan-Killiany,HCP-MMP,Brainnetome,Brodmann,Destrieux,Campbell,Flechsig,Mindboggle,Kleist,Smith,and EconomoCT atlases projected onto surface each image then converted volumetric labels. also nonlinearly registered using ANTs-SyN MNI152-6thgen,MNI-Colin,and MNI-2009b templates, Harvard-Oxford,Julich,AAL3,Buckner,CoBrALab,CAREN,Striatum-subdivision Hippocampal-subfields warped image. ANTs-derived transformations applied on individual build template used map corresponding raw exact physical locations final space. performance segmentation a separate group 100 adult individuals was evaluated terms label overlap, geometry, dissimilarity when comparing individual’s space, respective reference source Result Examples are shown Figure1. measures overlap between set generally high, an average Dice coefficient 0.78±0.3, Jaccard 0.59±0.27(Fig.2), sensitivity 0.74±0.1, specificity 0.86±0.35(Fig.3). geometry showed high correlation both volume label(correlation = 0.997,p-value<10−10) area 0.991,p-value<10−10)(Fig.4). values low, error 0.38±0.2(Fig.5). Conclusion MIITRA, combination high-resolution atlas, allowed that is good agreement