A comparative study of narrowband-ultraviolet B plus intralesional normal saline versus narrowband-ultraviolet B with platelet rich plasma in treatment of vitiligo

Background: Treatment of vitiligo remains a challenge and there is no universal consensus about optimal treatment. Platelet rich plasma contains several growth factors being used as an effective treatment dermatological disorders. Now it clear that along with melanocytes, keratinocytes fibroblasts are also involved in pathogenesis vitiligo. The aim this study was to compare the effect narrowband-ultraviolet B (NB-UVB) platelet versus NB-UVB intralesional normal saline Methods: A prospective observational done between March 2016 August 2017 on patients attending BRD Medical College, Gorakhpur. total 80 were enrolled symmetrical lesions. For each patient one side treated platelet-rich (PRP) other NB- UVB plus given. Intralesional PRP given interval every 2 weeks for 4 months receiving therapy thrice weekly alternate day. Results: We found combination NB had statistically significant improvement compared alone pigmentation detected 60% combined site 20% saline. Conclusions: Intradermal injections efficacious, safe, cheap easy technique more efficacious when therapy. It shortens duration