A Combination of Natural Products, BenPros (Green Tea Extract, Soybean Extract and Camellia Japonica Oil), Ameliorates Benign Prostatic Hyperplasia

Benign prostatic hyperplasia (BPH) is one of the most common diseases in elderly men and causes lower urinary tract symptoms due to excessive proliferation prostate stromal epithelial cells. The present study investigated improving effect BenPros, an edible natural product mixture (green tea extract, soybean extract camellia japonica oil), against development BPH vitro vivo. BenPros treatment showed inhibitory ability on testosterone-induced androgen receptor, prostate-specific antigen (PSA), 5α-reductase protein expression LNCap-LN3 cells anti-inflammatory effects LPS-induced increases interleukin-6 tumor necrosis factor-α RAW264.7 In a testosterone propionate (TP)-induced rat model, decreased up-regulated serum 5α-dihydrotestosterone PSA levels. Moreover, also significantly reduced tissue. Furthermore, TP-induced increased cyclooxygenase 2 B-cell lymphoma (Bcl-2) were by resulting increase Bcl-2/BCL2-related X ratio. These regulatory abilities inducing markers size thickness based histological analysis. results indicate that has protective vivo, it may be promising candidate as functional food regulating BPH.