A clinical pharmacologist's view of drug toxicity

Critical appraisal rounds: a new training model for clinical pharmacologists.

A new training model for critical appraisal in therapeutics is presented. Postgraduate trainees in Clinical Pharmacology are assigned to critically appraise scientific papers that faculty members were asked to review by Journals. The manuscripts were discussed in group rounds, allowing teaching of all aspects of therapeutics research. Formal evaluation of this model by trainees revealed high ma...

Drug-related problems and factors influencing acceptance of clinical pharmacologists` alerts in a large cohort of neurology inpatients.

QUESTIONS UNDER STUDY/PRINCIPLES Data regarding the prevalence and types of drug-related problems (DRPs) among neurology inpatients is sparse. The objective of this study was to characterise the types of DRPs seen among neurology inpatients and furthermore to study factors affecting the acceptance of clinical pharmacologists' and pharmacists' recommendations for improving drug safety. METHODS...

Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists.

[Drug interchangeability: clinical approach and consumer's point of view].

The rational construction of an essential drug list, considering the patient's need, drug safety, availability and the best cost-benefit ratio, is based on drug safety, efficacy and quality. However, in daily practice, the prescriber's decision is mostly influenced by drug effectiveness, following criteria that increase adherence to the treatment, such as relative drug toxicity, convenience, co...

Drug Toxicity

Physicians prescribe drugs to prevent or treat disease. Those same drugs can be toxic to certain patients, however, because of genetic predisposition, nonselective action, or inappropriate use or administration of the drug. The United States Food and Drug Administration (FDA) spends a significant portion of its $1 trillion budget to ensure that new drugs are not overtly or unnecessarily dangero...