A chemical synthesis of 11-methoxy mitragynine pseudoindoxyl featuring the interrupted Ugi reaction
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چکیده
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mesuring the staff technology readiness, the case of a multi national chemical company operating in iran
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15 صفحه اولSynthesis of multivalent aminoglycoside mimics via the Ugi multicomponent reaction.
The synthesis of multivalent neoglycoconjugates with 2,6-diamino-2,6-dideoxyglucose is accomplished by a flexible Ugi multicomponent approach leading to mono-, di- and tri-valent carbohydrate clusters.
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We have previously elucidated the opiate-like action of mitragynine, an active principle isolated from the Thai medicinal plant Mitragyna speciosa. In the present study, effects of the related compound, mitragynine pseudoindoxyl on electrically stimulated contraction in guinea pig ileum and mouse vas deferens, and on its binding affinity in the guinea pig brain membranes were studied. Mitragyni...
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The second-generation synthesis of 3'-hydroxypacidamycin D (2) has been accomplished via an Ugi-four component reaction at a late stage of the synthesis. This approach provided ready access to a range of analogues including diastereomers of the diaminobutylic acid residue and hybrid-type analogues of mureidomycins. Biological evaluations of these analogues indicated that the stereochemistry at ...
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ژورنال
عنوان ژورنال: Chemical Science
سال: 2012
ISSN: 2041-6520,2041-6539
DOI: 10.1039/c2sc20669b