A Charge Reversal Differentiates (p)ppGpp Synthesis by Monofunctional and Bifunctional Rel Proteins
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چکیده
منابع مشابه
A charge reversal differentiates (p)ppGpp synthesis by monofunctional and bifunctional Rel proteins.
A major regulatory mechanism evolved by microorganisms to combat stress is the regulation mediated by (p)ppGpp (the stringent response molecule), synthesized and hydrolyzed by Rel proteins. These are divided into bifunctional and monofunctional proteins based on the presence or absence of the hydrolysis activity. Although these proteins require Mg(2+) for (p)ppGpp synthesis, high Mg(2+) was sho...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2007
ISSN: 0021-9258
DOI: 10.1074/jbc.m704828200