A Centrosome Kinase Modulates Antitumor Drug Sensitivity
نویسندگان
چکیده
منابع مشابه
Centrosome-associated NDR kinase regulates centrosome duplication.
Human NDR kinases are upregulated in some cancer types, yet their functions still remain undefined. Here, we report the first known function of a mammalian NDR kinase by demonstrating that human NDR directly contributes to centrosome duplication. A subpopulation of endogenous NDR localizes to centrosomes in a cell-cycle-dependent manner. Overexpression of NDR resulted in centrosome overduplicat...
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ژورنال
عنوان ژورنال: Cancer Cell
سال: 2010
ISSN: 1535-6108
DOI: 10.1016/j.ccr.2010.07.008