A Cellular Mechanism for Prepulse Inhibition

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چکیده

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A Cellular Mechanism for Prepulse Inhibition

In prepulse inhibition (PPI), startle responses to sudden, unexpected stimuli are markedly attenuated if immediately preceded by a weak stimulus of almost any modality. This experimental paradigm exposes a potent inhibitory process, present in nervous systems from invertebrates to humans, that is widely considered to play an important role in reducing distraction during the processing of sensor...

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Axonal conduction block as a novel mechanism of prepulse inhibition.

In prepulse inhibition (PPI), the startle response to a strong, unexpected stimulus is diminished if shortly preceded by the onset of a different stimulus. Because deficits in this inhibitory gating process are a hallmark feature of schizophrenia and certain other psychiatric disorders, the mechanisms underlying PPI are of significant interest. We previously used the invertebrate model system T...

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Prepulse-elicited startle in prepulse inhibition.

BACKGROUND Prepulse inhibition (PPI) has become a major experimental paradigm in the study of psychiatric disorders. In this study, a potential confound in measurement and interpretation of PPI, namely startle reactions to so-called "nonstartling" prepulses, was examined. METHODS Prepulses of 80, 85, and 90 dB(A) were presented on their own or followed by a pulse of 115 dB(A) (lead interval: ...

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A Neural Network Model of Prepulse Inhibition

The authors introduce a real-time model of acoustic prepulse inhibition (PPI) and facilitation (PPF) in animals and humans. The model incorporates excitatory and facilitatory pathways activated by the positive value of changes in noise level in the environment and an inhibitory pathway activated by the absolute value of changes in noise level. Whereas excitation and facilitation are exponential...

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Reflex excitability regulates prepulse inhibition.

Presentation of a weak stimulus, a prepulse, before a reflex-evoking stimulus decreases the amplitude of the reflex response relative to reflex amplitude evoked without a preceding prepulse. For example, presenting a brief tone before a trigeminal blink-eliciting stimulus significantly reduces reflex blink amplitude. A common explanation of such data are that sensory processing of the prepulse ...

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ژورنال

عنوان ژورنال: Neuron

سال: 2003

ISSN: 0896-6273

DOI: 10.1016/s0896-6273(03)00731-1