A Cautionary Tale: Fatal Lactic Acidosis Complicating Nucleoside Analogue and Metformin Therapy
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چکیده
منابع مشابه
A cautionary tale: fatal lactic acidosis complicating nucleoside analogue and metformin therapy.
mining subcellular localization of HCVgenomic RNA in lymphocytes. The aim of our study was merely to determine whether the cervical smear cells obtained from HCV-seropositive women were infected with HCV genomic RNA. We will include the subcellular staining of HCVinfected cells in our continuing study. FISH was performed in accordance with the protocol by Pinkel et al. [3]. The sequence of the ...
متن کاملLactic Acidosis Complicating Metformin and Non-Nucleoside Reverse Transcriptase Inhibitor Combination Therapy: A Smoldering Threat in the Post-HAART Era.
Dear Editor, The prevalence of type 2 diabetes (DM-2) in HIV-infected patients and the concomitant use of metformin (MTF) and non-nucleoside reverse transcriptase inhibitors (NRTI) is rising. Through inhibition of NADH dehydrogenase and DNA pol-γ, both drugs hinder oxidative phosphorylation that may lead to lactic acidosis (LA). Among NRTIs, abacavir and tenofovir have the lowest mitochondrial ...
متن کاملMetformin and Lactic Acidosis
Probably the most common mechanism by which metformin elevates blood lactate is by inducing catecholamine release in those who regulate or prescribe it. Caution in restricting the use of metformin for the treatment of type 2 diabetes has been rationalized on the basis of J) its chemical identity as a biguanide, 2) its ability to modify hepatic intermediary metabolism, 3) its administration to i...
متن کاملMetformin-Associated Lactic Acidosis
Metformin has been used in Europe since the 1970s to treat type 2 diabetes mellitus (T2DM). Usage has increased since the results of the UK Prospective Diabetes Study were published [1]. Metformin is widely endorsed as initial therapy by professional organizations because of low cost, a good safety profile, and potential protection against cardiovascular disease [2]. Therefore, it is now consid...
متن کاملMetformin-associated lactic acidosis.
: Metformin is the most commonly prescribed oral antidiabetic agent. Despite a good safety profile in most patients with diabetes, the risk of metformin-associated lactic acidosis is real if safety guidelines are ignored. Experience with 3 cases of metformin-associated lactic acidosis is reported. Two cases were caused by inappropriate use of metformin in the presence of renal, cardiac and hepa...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2003
ISSN: 1058-4838,1537-6591
DOI: 10.1086/375850