A CatalyCEST MRI Contrast Agent that Can Simultaneously Detect Two Enzyme Activities
نویسندگان
چکیده
منابع مشابه
A single diamagnetic catalyCEST MRI contrast agent that detects cathepsin B enzyme activity by using a ratio of two CEST signals.
CatalyCEST MRI can detect enzyme activity by monitoring the change in chemical exchange with water after a contrast agent is cleaved by an enzyme. Often these molecules use paramagnetic metals and are delivered with an additional non-responsive reference molecule. To improve this approach for molecular imaging, a single diamagnetic agent with enzyme-responsive and enzyme-unresponsive CEST signa...
متن کاملA novel MRI contrast agent synthesized by ion exchange method
Objective: In this study, the zeolite-coated iron oxide nanoparticles were evaluated as MRI contrast agent and effect of the nanocomposite synthesis method on MRI contrast was tested. Materials and Methods: Ion exchange method was used for synthesis of iron oxide-zeolite and the as prepared nanocomposite was characterized by XRD, FESEM and TEM. The nanocomposite toxicity in the cell culture, a...
متن کاملA self-calibrating PARACEST MRI contrast agent that detects esterase enzyme activity.
The CEST effect of many PARACEST MRI contrast agents changes in response to a molecular biomarker. However, other molecular biomarkers or environmental factors can influence CEST, so that a change in CEST is not conclusive proof for detecting the biomarker. To overcome this problem, a second control CEST effect may be included in the same PARACEST agent, which is responsive to all factors that ...
متن کاملReceptor-mediated Uptake of an Enzyme-activated Mri Contrast Agent
In recent report (Nature Biotechnology 2000, 16:321-325) we presented a new approach for obtaining high resolution in vivo images of gene expression using magnetic resonance imaging (MRI). We prepared MRI contrast agents in which the access of water to the fust coordination sphere of a chelated paramagnetic ion is blocked with a galactopyranose residue that can he cleaved by beta-galactosidase,...
متن کاملHydrothermal Synthesis of an Ethiodol Based Ferrofluid as a Potential MRI Contrast Agent
In the present work, stable ferrofluids containing oleic acid capped magnetite nanoparticles were synthesized via low temperature hydrothermal method. The physical and chemical properties of the synthesized particles were studied using TEM, XRD, AFM, VSM and PCS techniques. Mean particles size of the samples was between 4.5 and 10 nanometers, depending on experimental conditions. Effect ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ChemBioChem
سال: 2016
ISSN: 1439-4227
DOI: 10.1002/cbic.201500586