A Case of Primary Intraocular Lymphoma Treated by Intravitreal Methotrexate
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چکیده
منابع مشابه
A Case of Primary Intraocular Lymphoma Treated by Intravitreal Methotrexate
A 40-year-old female visited our clinic for visual disturbance of the right eye, in which a few creamy-yellow retinal lesions and visual field constrictions were noted. She had been treated for primary CNS lymphoma and was in complete remission. After failure to follow-up for three months, she lost vision in the right eye, at which time active panuveitis was seen. Decreased vision and field con...
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Intraocular non Hodgkin's lymphoma has traditionally been treated with radiotherapy or systemic chemotherapeutic agents. Unfortunately, radiotherapy rarely leads to a long term remission, and can only be safely administered once. Systemic chemotherapy has limited intraocular penetration. Intravitreal administered methotrexate is highly effective at inducing remission and is well tolerated. A ca...
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In order to prevent central nervous system (CNS) involvement and improve the prognosis of primary intraocular lymphoma (PIOL), we prospectively evaluated the efficacy of combined therapy using intravitreal methotrexate (MTX) and systemic high-dose MTX on treatment-naïve PIOL. Patients with newly diagnosed PIOL whose lymphoma was limited to the eyes were enrolled. The patients were treated with ...
متن کاملPharmacokinetics and toxicity of intravitreal chemotherapy for primary intraocular lymphoma.
OBJECTIVE To investigate the pharmacokinetics and toxicity of intravitreal chemotherapeutic agents in the rabbit eye for the potential treatment of primary intraocular lymphoma and other intraocular malignancies. METHODS The ocular pharmacokinetics of intravitreal methotrexate sodium (400 microg) was studied in 10 New Zealand white rabbits, and a single-compartment, first-order elimination mo...
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Primary intraocular lymphoma can occur as an isolated eye tumor or involve both the globe and the central nervous system [I]. Secondary lymphoma may also involve the eye as a result of a systemic tumor [2-51. The syndrome was first recognized in 1951 by Cooper and Riker [6], and numerous cases have been reported since [I-271. The initial term for this non-Hodgkin's lymphoma was reticulum cell s...
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ژورنال
عنوان ژورنال: Korean Journal of Ophthalmology
سال: 2009
ISSN: 1011-8942
DOI: 10.3341/kjo.2009.23.3.210