A case mimicking chronic myeloid leukemia with t(8;22)(p11;q11)/BCR-FGFR1 and sequential transformation to B-acute lymphoblastic leukemia and acute myeloid leukemia

Myeloid/lymphoid neoplasm is a rare malignancy with an aggressive course and rapid transformation to acute myeloid leukemia (AML), or less frequently lymphoblastic (ALL). Cases t(8;22)(p11;q11) BCR-FGFR1 fusion gene may be misdiagnosed chronic (CML), due very similar morphologic clinical profile. We report case of 48-year-old woman who complained weakness gastric pain. She had splenomegaly, eosinophilia, elevated white blood cells. Bone marrow (BM) aspiration biopsy was performed initial diagnosis CML. Cytogenetic analysis the BM showed 46,XX,t(8;22)(p11.2;q11.2). diagnosed myeloid/lymphoid eosinophilia rearrangement FGFR1 gene. Throughout phase, patient treated hydroxurea. Additional chromosomal abnormalities developed during therapy. Owing (8;22) clone, our did not respond treatment rapidly transformed first B-ALL then AML. To best knowledge, this MPN BCR genes