A brave new MYC-amplified world

A brave new MYC-amplified world

a basic domain helix-loop-helix leucine zipper (bHLH-LZ) transcriptional regulator that forms a heterodimer with the related but much smaller bHLH-LZ protein Max to bind sequence-specifically to DNA. In the last few years, the understanding of MYC action has undergone a complete transformation. Originally thought of as a conventional transcription factor with a large but limited number of disti...

A Brave New Integration World

Brave New World

Scientific publishing began in 1665 with the inauguration of the Journal des sçavans in France and the Philosophical Transactions of the Royal Society in England. These enterprises established the pattern that has endured to the present: that of a learned publication, financed privately, which shared knowledge within a select circle. By recording a date of publication, claims of scientific prio...

Brave New World

Written in 1931 and published the following year, Aldous Huxley’s Brave New World is a dystopian—or anti-utopian—novel. In it, the author questions the values of 1931 London, using satire and irony to portray a futuristic world in which many of the contemporary trends in British and American society have been taken to extremes. Though he was already a best-selling author, Huxley achieved intern...

Brave new RNA world.

In 1995, you could still find, in the opening paragraphs of manuscripts and grant applications from my lab and others, the phrase “In the absence of a crystal structure for the ribosome....,” by way of rationalizing any number of biochemical studies aimed at figuring out the three-dimensional locations of things inside the ribosome, and ultimately its mechanism. We no longer have this excuse. T...