A Biocompatible Dual‐Sided Hernia Mesh with Side‐Specific Properties

Polypropylene (PP) based hernia mesh often shows multiple post-surgery complications due to lack of biocompatibility, poor cell attachment, and unwanted tissue adhesion. These limitations can be addressed by material designing surface modification a with side-specific properties such as the visceral side (facing intestine) low protein attachment parietal incision) improved for normal healing. However, development dual-sided is very challenging because its porous structure. Herein, biocompatible anti-adsorption on two different sides developed grafting highly hydrophilic 2-methcryloyloxyethyl phosphorylcholine polymer (PMPC) plasma-activated side, while coated bioactive chitosan functionalized nanodiamond (Chi/FND) using temporary polyvinyl alcohol (PVA) mold. The PMPC-grafted demonstrated excellent resistance adsorption (96% reduction compared PP) attachment. coating has significantly proliferation properties. In addition, both confirmed presence respective biomaterials after an accelerated degradation study 28 days. Hence, newly semi-solid mold (SSPM) method promising candidate address long-existing issues mesh.