A Bayesian graphical modeling approach to microRNA regulatory network inference
نویسندگان
چکیده
منابع مشابه
A Bayesian Graphical Modeling Approach to Microrna Regulatory Network Inference.
It has been estimated that about 30% of the genes in the human genome are regulated by microRNAs (miRNAs). These are short RNA sequences that can down-regulate the levels of mRNAs or proteins in animals and plants. Genes regulated by miRNAs are called targets. Typically, methods for target prediction are based solely on sequence data and on the structure information. In this paper we propose a ...
متن کاملBayesian approach to inference of population structure
Methods of inferring the population structure, its applications in identifying disease models as well as foresighting the physical and mental situation of human beings have been finding ever-increasing importance. In this article, first, motivation and significance of studying the problem of population structure is explained. In the next section, the applications of inference of p...
متن کاملInference of a genetic network by a combined approach of cluster analysis and graphical Gaussian modeling
MOTIVATION Recent advances in DNA microarray technologies have made it possible to measure the expression levels of thousands of genes simultaneously under different conditions. The data obtained by microarray analyses are called expression profile data. One type of important information underlying the expression profile data is the 'genetic network,' that is, the regulatory network among genes...
متن کاملBayesian Graphical Modeling for
Conventional Intelligent Tutoring Systems (ITS) do not acknowledge uncertainty about the student's knowledge. Yet, both the outcome of any teaching intervention and the exact state of the student's knowledge are uncertain. In recent years, researchers have made startling progress in the management of uncertainty in knowledge-based systems. Building on these developments, we describe an ITS arch...
متن کاملAn Improved LAZY-AR Approach to Bayesian Network Inference
We propose LAZY arc-reversal with variable elimination (LAZY-ARVE) as a new approach to probabilistic inference in Bayesian networks (BNs). LAZY-ARVE is an improvement upon LAZY arcreversal (LAZY-AR), which was very recently proposed and empirically shown to be the state-of-the-art method for exact inference in discrete BNs. The primary advantage of LAZY-ARVE over LAZY-AR is that the former onl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Annals of Applied Statistics
سال: 2010
ISSN: 1932-6157
DOI: 10.1214/10-aoas360