A Bacteriophage Microgel Effectively Treats the Multidrug-Resistant Acinetobacter baumannii Bacterial Infections in Burn Wounds
نویسندگان
چکیده
Multidrug-resistant (MDR) Acinetobacter baumannii (A. baumannii) is one of the major pathogens present in burn wound infections. Biofilm formation makes it further challenging to treat with clinically available antibiotics. In current work, we isolated A. baumannii-specific bacteriophages (BPABΦ1), loaded into chitosan microparticles followed by dispersion gel, and evaluated therapeutic efficacy against MDR clinical strains. Isolated BPABΦ1 were found belong Corticoviridae family, burst size 102.12 ± 2.65 PFUs per infected host cell. The for quality attributes viz. size, PDI, surface morphology, vitro release, etc. developed formulation exhibited excellent antibiofilm eradication potential effective healing after topical application.
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ژورنال
عنوان ژورنال: Pharmaceuticals
سال: 2023
ISSN: ['1424-8247']
DOI: https://doi.org/10.3390/ph16070942