منابع مشابه
The riboswitch control of bacterial metabolism.
Aptamers are artificial nucleic acids that selectively bind small molecules. In the past two years, it has become clear that nature has already devised its own aptamers that play important regulatory roles. RNA sensors have been discovered in both Gram-positive and Gram-negative bacteria that function as molecular switches in response to direct binding of structurally diverse metabolites. These...
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A lthough Escherichia coli is a prototypic commensal bacterial species of the mammalian intestine and a laboratory workhorse for molecular biology, certain strains of this species are capable of causing significant human disease. The spectrum of disease caused by E. coli includes enteric/diarrheal disease, urinary tract infections, renal failure, and sepsis/meningitis (1). The different pathoty...
متن کاملThe EspF effector – a bacterial pathogen ’ s
10 Central to the pathogenesis of many bacterial pathogens is the ability to deliver effector 11 proteins directly into the cells of their eukaryotic host. EspF is one of many effector proteins 12 exclusive to the attaching and effacing pathogen family that includes enteropathogenic 13 (EPEC) and enterohemorrhagic E. coli (EHEC). Work in recent years has revealed EspF to be 14 one of the most m...
متن کاملBacterial pathogen genomics and vaccines.
Infectious diseases remain a major cause of deaths and disabilities in the world, the majority of which are caused by bacteria. Although immunisation is the most cost effective and efficient means to control microbial diseases, vaccines are not yet available to prevent many major bacterial infections. Examples include dysentery (shigellosis), gonorrhoea, trachoma, gastric ulcers and cancer (Hel...
متن کاملBacterial Genomics and Pathogen Evolution
The availability of hundreds of bacterial genome sequences has altered the study of bacterial pathogenesis, affecting both design of experiments and analysis of results. Comparative genomics and genomic tools have been used to identify virulence factors and genes involved in environmental persistence of pathogens. However, a major stumbling block in the genomics revolution has been the large nu...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2009
ISSN: 1931-3128
DOI: 10.1016/j.chom.2009.10.009