منابع مشابه
HemoCue haemoglobin systems--a clarification.
The preferred method to verify the accuracy of a haemoglobinometer is the International Committee for Standardization in Haematology (ICSH) reference measurement of haemoglobin as haemiglobincyanide in whole blood, using a spectrophotometer which has been calibrated directly by the WHO/ICSH primary international reference standard or by means of a commercial standard that has been manufactured ...
متن کاملPersistent fetal haemoglobin and falsely high glycosylated haemoglobin levels.
Some of the routine methods of measuring glycosylated haemoglobin depend on its difference in charge from haemoglobin A and do not distinguish between glycosylated haemoglobin and fetal haemoglobin. Two insulin dependent diabetics showed persistent discrepancies between their capillary blood glucose values and their glycosylated haemoglobin values measured by agar gel electrophoresis: the blood...
متن کاملComplete suppression of haemoglobin A synthesis in haemoglobin D Los Angeles--beta thalassaemia.
A family study is reported in which all three siblings were shown to be doubly heterozygous for haemoglobin D Los Angeles and beta thalassaemia, which resulted in a complete suppression of haemoglobin A synthesis. This demonstrates the effects of genetic interaction which occur when the genes for haemoglobin D Los Angeles and beta thalassaemia are both transmitted to the offspring. The importan...
متن کاملAHSP (α-haemoglobin-stabilizing protein) stabilizes apo-α-haemoglobin in a partially folded state.
To produce functional Hb (haemoglobin), nascent α-globin (αo) and β-globin (βo) chains must each bind a single haem molecule (to form αh and βh) and interact together to form heterodimers. The precise sequence of binding events is unknown, and it has been suggested that additional factors might enhance the efficiency of Hb folding. AHSP (α-haemoglobin-stabilizing protein) has been shown previou...
متن کاملNew 13-Chain Variant of Haemoglobin A Found in Combination with Haemoglobin S
During a routine study of the parents of a 3month-old Jamaican child with the sickle-cell trait the father was found to have a haemoglobin electrophoretic pattern identical to that of homozygous sickle-cell disease. Because he was perfectly well and had no haematological abnormalities detailed studies of his haemoglobin constitution were undertaken. These indicate that he is heterozygous for bo...
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ژورنال
عنوان ژورنال: Nature
سال: 1986
ISSN: 0028-0836,1476-4687
DOI: 10.1038/322405a0