A 2cM genome-wide scan of European Holstein cattle affected by classical BSE
نویسندگان
چکیده
منابع مشابه
Genome-Wide Scan Identifies Loci Associated with Classical BSE Occurrence
Classical bovine spongiform encephalopathy (BSE) is an acquired prion disease that is invariably fatal in cattle and has been implicated as a significant human health risk. Sequence variations in the coding region of the prion gene (PRNP) have been associated with acquired transmissible spongiform encephalopathy (TSE) susceptibility in mammals; however, this is not the case in cattle. It has be...
متن کاملPRNP Haplotype Associated with Classical BSE Incidence in European Holstein Cattle
BACKGROUND Classical bovine spongiform encephalopathy (BSE) is an acquired prion disease of cattle. The bovine prion gene (PRNP) contains regions of both high and low linkage disequilibrium (LD) that appear to be conserved across Bos taurus populations. The region of high LD, which spans the promoter and part of intron 2, contains polymorphic loci that have been associated with classical BSE st...
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BACKGROUND Bovine tuberculosis is a significant veterinary and financial problem in many parts of the world. Although many factors influence infection and progression of the disease, there is a host genetic component and dissection of this may enlighten on the wider biology of host response to tuberculosis. However, a binary phenotype of presence/absence of infection presents a noisy signal for...
متن کاملA genome-wide scan for signatures of recent selection in Holstein cattle.
The data from the newly available 50 K SNP chip was used for tagging the genome-wide footprints of positive selection in Holstein-Friesian cattle. For this purpose, we employed the recently described Extended Haplotype Homozygosity test, which detects selection by measuring the characteristics of haplotypes within a single population. To assess formally the significance of these results, we com...
متن کاملGenome wide scan for somatic cell counts in holstein bulls
BACKGROUND Mastitis is the most costly disease for dairy production, and control of the disease is often difficult, due to its multi-factorial nature. Susceptibility to mastitis is under partial genetic control and the industry uses indirect selection for decreased concentrations of somatic cells in milk to reduce mastitis. METHODS A genome-wide scan was performed to identify genomic regions ...
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ژورنال
عنوان ژورنال: BMC Genetics
سال: 2010
ISSN: 1471-2156
DOI: 10.1186/1471-2156-11-20