A-165 Selective Mutism in Pediatric Opsoclonus-Myoclonus Syndrome: A Case Study

Abstract Objective: Opsoclonus-Myoclonus Syndrome (OMS) is an extremely rare (1 per 5 million estimated incidence), subacute movement disorder characterized by myoclonus and/or ataxia, opsoclonus, and behavioral disturbance with or without neuroblastoma. Many pediatric patients will experience long-term cognitive, behavioral, motor sequelae. This case study describes deficits associated a course of OMS present poly-etiologic hypothesis for the observed profile. Improved understanding phenotypic variance in atypical may promote diagnostic clarity subsequent intervention presentation that scientifically underserved. Method: Patient presented viral infection at 2 years age led to loss speech functioning ultimately diagnosis OMS. exhibited typical features cerebellar mutism syndrome (mutism, emotional lability, impairment), rapid recovery gross skills. Patient’s has persisted several despite immunomodulatory treatment normal neuroimaging findings. Results: Neuropsychological results indicated below average performance across intellectual, language, motoric, academic domains. Functional adaptive impairments secondary social anxiety separation distress were also exhibited. Diagnostic criteria Selective Mutism Social Anxiety Disorder met. Significant anxiety, post-event stress, attachment needs, altered speech/language development, personal temperament are all probable contributors her prolonged mutism. Conclusions: examines Mutism, while not uncommon some disorders post surgically, well documented literature represent outcome. These findings add variability, developmental course, profile presentations.