980 Low fetal fraction in IVF pregnancies associated with hypertensive disorders of pregnancy

Fetal outcome in hypertensive disorders of pregnancy.

Fetal outcome was evaluated in 157 hypertensive pregnant women whose underlying disease had been established by renal biopsy. The patients had pathologic diagnoses of preeclampsia (95), nephrosclerosis (23), nephrosclerosis with superimposed preeclampsia (13), interstitial and tubular nephropathy (seven), and normal findings (six). Pregnancy outcome in this selected group of patients was extrem...

Pharmacovigilance in pregnancy: adverse drug reactions associated with fetal disorders.

OBJECTIVE To provide the first update on drug safety profiles and adverse drug reactions (ADRs) associated with fetal disorders from the Swiss national ADR database. METHODS We conducted a retrospective study using data from 202 pharmacovigilance reports on drug-associated fetal disorders from the Swiss national ADR database from 1990 to 2009. Evaluated aspects included administrative informa...

Hypertensive Disorders in Pregnancy

Cell-free fetal DNA levels in pregnancies conceived by IVF.

BACKGROUND Increased second-trimester levels of maternal serum HCG in IVF conceptions lead to an increased false-positive rate in Down syndrome screening. Increased levels of cell-free fetal DNA (cffDNA) in maternal plasma have been correlated with increased HCG levels. Our aim was to determine whether cffDNA levels are elevated in IVF pregnancies compared with natural pregnancies. METHODS Si...

Hypertensive disorders in pregnancy

Hypertensive disorders in pregnancy (HDP) affect 10% of pregnant patients and are the second most common cause of maternal mortality and adverse fetal outcomes in developed countries. HDP is a group of diseases that includes preeclampsia, eclampsia, pregnancy induced hypertension and HELLP syndrome. Inadequate placentation, immune intolerance and genetics are accounted as possible etiological f...