953-35 Reduction of Nitric Oxide Induced Reoxygenation Injury in the Cyanotic Immature Heart by Controlling Oxygen Content
نویسندگان
چکیده
منابع مشابه
Oxygen reduction by nitric-oxide synthases.
Nitric-oxide synthases (NOS, EC 1.14.13.39) are hemeproteins that catalyze oxidation of L-arginine to NOz and L-citrulline. Three main isozymes exist in mammals that are regulated by distinct genes (1–6): a constitutive neuronal NOS (nNOS or NOS I), (7, 8), an endotoxinand cytokine-inducible NOS (iNOS or NOS II) (9, 10), and a constitutive endothelial NOS (eNOS or NOS III) (11). Although NOS ha...
متن کاملNitric oxide metabolism in adults with cyanotic congenital heart disease.
Endothelial-derived nitric oxide (NO) diffuses abluminally to regulate blood flow by activating soluble guanylate cyclase in medial smooth muscle. However, a significant fraction of NO diffuses luminally, where the extremely high reaction rate with red blood cell hemoglobin (Hb) effectively reduces luminal concentration to zero. The erythrocytosis of cyanotic congenital heart disease has potent...
متن کاملNitric oxide scavenging modulates mitochondrial dysfunction induced by hypoxia/reoxygenation.
The objective of the present study was to delineate the role of excessive accumulation of mitochondrial nitrogen species contributing to oxidative stress induced by hypoxia/reoxygenation in isolated mitochondria. The present study shows that incubation of isolated rat heart mitochondria under hypoxic, but not anoxic conditions, followed by reoxygenation decreases the rate of mitochondrial oxyge...
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در این پایان نامه تاثیر دو نوع تست جزیی نگر و کلی نگر بر به یادسپاری محتوا ارزیابی شده که نتایج نشان دهندهکارایی تستهای کلی نگر بیشتر از سایر آزمونها است
15 صفحه اولProtection of Myocytes From Hypoxia-Reoxygenation Injury by Nitric Oxide Is Mediated by Modulation of Transforming
Background—Reoxygenation injury is a result of several complex events, including release of reactive oxygen species, protein kinase C (PKC) activation, and altered expression of transforming growth factor1 (TGF1). Nitric oxide (NO) generally protects tissues from reperfusion injury. Methods and Results—We examined the modulation of TGF1 expression and activity and PKC activation in cultured rat...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1995
ISSN: 0735-1097
DOI: 10.1016/0735-1097(95)92292-d