945 EFFECTIVENESS OF CREATINE SUPPLEMENTATION ON MEMORY IN HEALTHY INDIVIDUALS: A SYSTEMATIC REVIEW AND META-ANALYSIS

Abstract Introduction The benefit of creatine monohydrate supplementation in improving memory performance healthy humans is unclear. aim this study was to determine the effectiveness on humans. Method A literature search PubMed, Web Science, Cochrane Library, and Scopus for randomized clinical trials (RCTs) published from database inception until September 30, 2021, examining effects measures conducted. control groups consisted placebo. main outcome that were further examined according age, sex, treatment duration, dose supplementation. Results Ten RCTs met inclusion criteria 8 included meta-analysis. Overall, improved compared placebo (SMD: 0.29, 95% CI: 0.04–0.53, I2 = 66%, P 0.02). Subgroup analyses revealed a significant improvement older adults (66–76 years) 0.88, 0.22–1.55, 83%, 0.009). Creatine dose, duration intervention, sex did not influence findings. Conclusion These data support use enhances placebo, especially adults. However, caution warranted due combination various assessment tools designed measure memory, which would increase heterogeneity data.