90Y-DOTATOC as a Therapeutic Option for Complex Recurrent or Progressive Meningiomas

90Y-DOTATOC as a Therapeutic Option for Complex Recurrent or Progressive Meningiomas.

UNLABELLED The standard treatment of meningiomas is surgery or radiotherapy. Complex, especially recurrent or progressive cases, may exhibit tumor growth involving critical neurovascular structures or diffuse growth, resulting in limited efficacy and higher risk of standard treatment. We evaluated whether somatostatin receptor-targeted radionuclide therapy with (90)Y-DOTATOC may be a therapeuti...

Preparation of [64Cu] Pyruvaldehyde-bis (N4-methylthiosemicarbazone) complex as a PET and/or therapeutic radiopharmaceutical

Background: Copper-64 (T1/2=12.7 h) is an important radionuclide used both in PET imaging and therapy. [64Cu]-pyruvaldehyde-bis (N4-methylthiosemicarbazone) ([64Cu]-PTSM) is one of the most famous copper radiopharmaceuticals with unique specifications (suitable half life, stability, etc.). The wide range of 64Cu applications arouse great interest for its production. Materials and Methods: Cu-64...

Drug Therapy for Recurrent, Progressive, Atypical, and Malignant Meningiomas

Biokinetic and Dosimetry of 90y-dotatoc Therapy for Neuroendocrine Tumours

Biokinetic model is a mathematical model which describes the behavior of the Y in human body during the treatment of neuroendocrine tumours. This paper presents calculation of absorbed doses in human organs in biokinetic model Y for DOTATOC therapy. For this purpose, the human body is represented by five compartments: blood, kidneys, urinary bladder, tumour and liver. The input file was develop...

P 57: The Effect of Biotin as a Therapeutic Agent for Progressive Multiple Sclerosis

Multiple sclerosis is an autoimmune disease caused by damage to the myelin of the nerve cells in the spinal cord and brain, MS was classified into 4 types including: Relasping/remitting (RR) primary/progressive (PP), secondary/progressive (SP), progressive/relapsing (PR). PR MS is one of the severe forms of MS that lead to inflammation associated physical, mental and vision dysfunction. Because...