90 p16 IHC Validation on Cytology Cell Blocks
نویسندگان
چکیده
منابع مشابه
Utility of cytology microarray constructed from effusion cell blocks for immunomarker validation.
BACKGROUND Tissue microarray allows rapid and efficient evaluation of gene expression at the protein level and of immunochemical markers. To our knowledge, there has been no report of constructing cytology microarray using effusion cell blocks and testing its utility in immunochemical marker validation. METHODS A total of 23 malignant effusions (primary tumor of breast [5], GI tract [5], lung...
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BACKGROUND p16 (INK4a) (p16) is a well-recognized surrogate molecular marker for human papilloma virus (HPV) related squamous dysplasia. Our hypothesis is that the invasive interventions and related morbidities could be avoided by objective stratification of positive cytologic interpretations by p16 immunostaining of cell block sections of cytology specimens. MATERIALS AND METHODS Nuclear imm...
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Carcinoma of the oral tongue is one of the most common sub sites of oral cancer. Comparative worldwide studies have reported its incidence to be much higher in India (Moore et al., 2000; Mishra and Meherotra, 2014). In Chennai, India, oral tongue squamous cell carcinoma (OTSCC) represents 5% and 1.6% of incident cancers of all sites among males and females respectively as per the reports of pop...
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BACKGROUND Inevitable loss of diagnostic material should be minimized during cell block preparation. We introduce a modified agarose cell block technique that enables the synthesis of compact cell blocks by using the entirety of a cell pellet without the loss of diagnostic material during cell block preparations. The feasibility of this technique is illustrated by high-throughput immunocytochem...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2018
ISSN: 0002-9173,1943-7722
DOI: 10.1093/ajcp/aqx117.089