9. Vitamin K deficiency in practice

Vitamin K Deficiency Disease

Vitamin Kdeficiency bleeding (VKDB) previously known as hemorrhagic disease of the newborn has been classified as Early (0-24hrs), Classic (2-7 days) and Late (1-6 months). Child birth following the maternal ingestion of anti-epileptic drugs such as Phenytoin, is liable to result in early VKDB as well as bone changes in the fetus. Other maternal risk factors for VKDB include medications such as...

A case report of temporary and acquired vitamin K-dependent clotting factor deficiency without any response to administrated vitamin K

Abstract Background and Objectives Vitamin K-dependent clotting factor deficiency (VKCFD) is usually an acquired problem due to liver disease, malabsorption, and overdose of warfarin.  In the present paper the significance and role of vitamin K-dependent coagulation factors in menorrhagia were evaluated.   Case We present a rare case of 43 year woman with acquired vitamin K deficiency and se...

Oral anticoagulation and vitamin K deficiency.

A 61-year old woman with atrial fibrillation developed macrohaematuria during anticoagulant treatment with a direct oral factor Xa inhibitor for stroke prevention. Abnormal results of coagulation assays were first interpreted as an effect of the anticoagulant. However, upon further testing diagnosis of vitamin K deficiency was established. After vitamin K supplementation, coagulation tests norm...

Vitamin K Deficiency Embryopathy from Hyperemesis Gravidarum

A 21-year-old primigravida had a pregnancy complicated by hyperemesis gravidarum (HG) beginning at 7-week gestation. Despite medical therapy, she lost 18% of her prepregnancy weight. Early ultrasound at 14 weeks demonstrated a flattened facial profile with nasal hypoplasia (Binder phenotype) consistent with vitamin K deficiency from HG. She had a percutaneous endoscopic gastrojejunostomy tube p...

Purpura Caused by Vitamin K Deficiency