Δ9-Tetrahydrocannabinol (THC) impairs visual working memory performance: a randomized crossover trial

Treatment of Tourette-Syndrome with ∆-Tetrahydrocannabinol (THC): a randomized crossover trial

Default Mode Network in the Effects of Δ9-Tetrahydrocannabinol (THC) on Human Executive Function

Evidence is increasing for involvement of the endocannabinoid system in cognitive functions including attention and executive function, as well as in psychiatric disorders characterized by cognitive deficits, such as schizophrenia. Executive function appears to be associated with both modulation of active networks and inhibition of activity in the default mode network. In the present study, we ...

Social Communication Impairs Working-Memory Performance.

Performance on working-memory tests is frequently used in experimental psychology and neuroscience, as well as in neuropsychological testing and clinical screening. It can be strongly affected by the social context and the communication style of the experimenter. We tested this hypothesis in two experiments, examining standardized neuropsychological working-memory tests in different social comm...

Clozapine and SCH 23390 prevent the spatial working memory disruption induced by Δ9-THC administration into the medial prefrontal cortex

Marijuana (Cannabis sativa) is one of the most widely used illicit drugs in the world. Its use is associated with impairments in cognitive function. We previously reported that Δ(9)-tetrahydrocannabinol (Δ(9)-THC), the primary psychoactive component of marijuana, impaired spatial working memory in the radial maze task when injected intracortically (IC) into the medial prefrontal cortex (mPFC) o...

Increasing number of objects impairs binding in visual working memory

The number of objects that can be maintained in visual working memory without interference is limited. We present simulations of a model of visual working memory in ventral prefrontal cortex that has this constraint as well. One layer in ventral PFC represents all objects in memory. These representations are used to bind the features of the objects. If there are too many objects, their represen...